College: University of Otago, New Zealand
Thesis title: Designing oligoarginine-associated PECA nanoparticles for enhanced cellular uptake
Co-supervisors: Prof. Ian Tucker (School of Pharmacy, University of Otago), Dr Bernie McLeod (AgResearch, Invermay)
Project description: Poly(alkylcyanoacrylate) or PACA nanoparticles hold great potential and value in future oral delivery system. And now, with the recent discovery of cell-penetrating peptides (CPPs), superior oral bioavailability may be possible with the synergistic effect of CPPs incorporated into nanoparticulate systems. This revolution will make future oral medicines more effective.
I will be investigating the mechanisms involved in the uptake of PACA nanoparticles from the gut of the common brushtail possum and assessing any enhancement effect that CPPs can possibly provide.
After graduating, Jasper worked as Postdoctoral Fellow at the University of Otago.