Project title: Modeling CPP-nanoparticles in cell culture
Project description: Cell penetrating peptides (CPPs) are short cationic peptides that are of interest in drug delivery due to their ability to increase absorption, thus enhancing oral bioavailability. We have produced novel formulations of poly(ethly cyanoacrylate) PECA nanoparticles decorated with the CPP oligoarginine.
The interaction of CPP-nanoparticles with Caco-2 monolayers in cell culture underpins our predictions of how these formulations act in vivo. We are interested in modeling the in vitro behavior of CPP-nanoparticles to evaluate their enhanced permeability properties.