College: School of Pharmacy, University of Otago
Thesis title: Design and synthesis of novel Chlamydia drugs acting as inhibitors of the bacterial enzyme CtHtrA protease
Co-supervisors: Associate Professor Joel Tyndall (School of Pharmacy, University of Otago), Dr Allan Gamble (School of Pharmacy, University of Otago)
Chlamydia trachomatis is one of the leading causative agents of sexually transmitted infections. Recent clinical evidence indicates emergence of antibiotic resistance with the current first-line chlamydial antibiotic treatments. Thus, there is an urgent need to develop novel anti-chlamydia drugs. I am working on structure-based drug design to target CtHtrA protein responsible for chlamydial replication, virulence and survival under stress conditions. I am also researching delivery of antibacterial compound using a polymeric nanoparticle drug delivery system (PLGA nanoparticles) prepared using a microfluidic approach.